It is around 310 miles.
The route:
163 miles
117 miles
There are 202 miles between Naples, FL & Orlando, FL, according to travelmath.com.
255 miles
That would be 87.8 miles.
The distance from Gainesville, FL to Naples, FL is approximately 270 miles if driving via I-75 South.
123 miles
The distance from Spring Hill, FL to Naples, FL is approximately 177 miles via I-75 S.
42.77 miles
127.61 Miles
295 miles
It is 202.47 miles according to MapQuest.