It is 295.64 miles according to MapQuest.
There are approximately 291.75 miles between Orlando, FL and Key Largo. The estimated driving time is 4 hours and 22 minutes.
The distance from Key Largo, FL to Orlando, FL is approximately 330 miles.
289 miles taking this route:Take Florida's TURNPIKE (toll) SOUTH, from Orlando, to U.S. 1 SOUTH to KEY WEST at where Florida's TURNPIKE - ENDS in Homestead.Take U.S. 1 SOUTH to Key Largo.
It is 296 miles according to Google Maps.
286.3 mi 4h15m +/-
126 miles
6.9 miles
About 295 miles or four hours and forty five min. driving time
2,422 miles
It is 63.12 miles according to MapQuest.
Orlando to Key West is 393 miles. The Keys are about 120 miles long.