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Yes there are - many of them.
Mississippi and Missouri Rivers.
Missouri (and Columbia)
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According to Wikipedia, there are 17 Interstate highways in Missouri, with a total length of 1,193 miles.
The Missouri and the Ohio rivers are the two major rivers that merge into the Mississippi.
The Missouri does, the Colorado does not. It empties instead into the Sea of Cortez.
Missouri and Mississippi river
Mississippi and the Missouri rivers.
The largest river flowing thru the Midwest is the Mississippi. This river begins in Minnesota and flows all the way to the Gulf of Mexico. Most other rivers dump into this mighty river. This river forms the Eastern border of states like Iowa, and Missouri and others. There is also the Missouri river. This is a large river was used by Native Americans, fur traders and Lewis and Clark for exploration. This river forms the Western border of Iowa and flows through Missouri to the Mississippi. In Iowa there are many rivers. The Des Moines river is one of the largest rivers. In Nebraska, the Platte river branches into many areas before joining into one large river. There are many other rivers in the Midwest. These are just a few.
The Missouri and Mississippi Rivers come together just north of St. Louis.