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the mayflower set sail September 6, 1620
3.63
There was another ship that set sail for the new world with the Mayflower known as the Godspeed, but shortly after setting sail from England it started taking on water and had to return to England. yuyuiy
1,698
first off all the Mayflower did not set sale it set SAIL
April
11 ships
It was 16th of september, 1620
April 5,1621
1620
Southampton, England
Assuming you are referring to the English Separatists on the Mayflower, they left Southampton in two ships on August 6, 1620, but one of their ships, the Speedwell, was leaking, so they turned back. They set sail again from Plymouth (England) on September 6, 1620, in only one ship, the Mayflower.