How much will it cost a new roof on a 4000 square feet house?

It depends on a lot of variables, tear off or layover, what type of materials chosen, pitch and height make a difference in labor costs. Material for a tear off including felt, shingles nails, vents, pipe flashing, usually cost me around $110-$150 per square (100 square feet roof area not house area), depending on shingles used. figure about 21/2 - 4 times that cost with professional installation.