Before the test, the patient must stop taking all drugs that can inhibit acetylcholinesterase. The referring physician can advise on specific drugs the patient is taking.
The Tensilon test may cause heart rhythm abnormalities, especially in those patients with preexisting conditions.
Tensilon is the trade name for edrophonium chloride. The Tensilon test is an injection of edrophonium chloride used to diagnosis myasthenia gravis (MG).
No special preparations are necessary for this test.
This test requires a blood sample.
The effects of Tensilon subside quickly, and are completely gone after 30-60 minutes. No aftercare is needed.
A normal Tensilon test is characterized by an improvement in muscle weakness or ptosis within minutes of administering the drug edrophonium. This improvement is temporary and lasts for about 5-10 minutes. The test is positive in patients with myasthenia gravis.
The Tensilon test involves the intravenous injection of a small amount of Tensilon. The needle is left in place. If no adverse reaction is observed within 30 seconds, an additional volume is injected. Results are apparent within one minute.
By blocking the action of acetylcholinesterase, Tensilon prolongs the muscle stimulation, and temporarily improves strength. Increased strength following an injection of Tensilon strongly suggests a diagnosis of MG.
Patients should not drink alcoholic or caffeinated beverages, smoke tobacco, or ingest other nicotine products for 24 hours before the test. These substances can affect test results. Patients should also not eat anything.
atropine sulfate is used as an antidote of anticholinesterase meds administered on patients with myasthenia gravis. Atropine sulfate should be also made available when performing the Tensilon Test to reverse the effect of Edrophonium injection.
This test requires a blood sample. It is not necessary for the patient to be in a fasting (nothing to eat or drink) state before the test.
The patient should avoid strenuous exercise and have nothing to eat or drink, except water, for eight to ten hours before this test.