How smart would it be for somebody not interested in aviation to pursue a career as a Commercial Airlines Pilot and is it a smart career choice considering the potential for layoffs?

It would not be very wise. If you want to get into an aviation career you had better do it because you love to fly. It takes a tremendous commitment to build the hours and skill levels necessary to be a commercial pilot.

It would be like asking if a woman who enjoyed fashion design would like to be a ditch-digger, oil well foreman, or a coal miner. In other words, a person must match, as closely as possible, their interests to their career or job choices--or the person will quit a job they do not like or do not love.