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Often times, many did not. Outside of relatively cool regions like New England, disease was too rampant for many first generation settlers, though immunity grew over time. Those that could survive naturally did all they could to create survivable conditions, and their children had an easier time living in those circumstances.

If you could specify the colonized region, it would be a more specific answer

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Q: How were colonists able to overcome harsh weather lack of food lack of clothing and exposure to diseases?
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