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that depends on person but your drug should be freely soluble in in that volume , literature says volume should be 2,3 or sometime 5 times the volume to soluble the drug in that much of volume.

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12y ago

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Why dissolution media 900ml?

A 900 ml dissolution medium is a common volume used in dissolution testing to ensure that there is an adequate volume for the drug to dissolve, without saturating the medium too quickly. This volume is also a practical amount that can fit into standard dissolution vessels and be easily mixed and sampled throughout the test.


What is dissolution medium?

Dissolution medium is a liquid used in dissolution testing to simulate the fluids of the gastrointestinal tract and assess the release of drug substances from pharmaceutical dosage forms. It typically contains various components such as electrolytes, buffers, and surfactants to mimic physiological conditions and ensure accurate measurement of drug dissolution rates.


What is the formula for Dissolution calculation with media replacement?

The formula for dissolution calculation with media replacement typically involves determining the concentration of the solute in the dissolution medium over time. The general equation can be expressed as: [ \text{C}(t) = \frac{V_s}{V_t} \cdot \text{C}_s + \left(1 - \frac{V_s}{V_t}\right) \cdot \text{C}(t-Δt)] where (C(t)) is the concentration at time (t), (V_s) is the volume of the sample taken, (V_t) is the total volume of the medium, (C_s) is the concentration of the solute in the sample, and (C(t-Δt)) is the concentration at the previous time point. This formula accounts for the changes in concentration as media is replaced during the dissolution process.


The what of a medium is how much matter or mass there is in a given volume?

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What is the dissolution medium for Rabeprazole enteric coated Tablet?

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