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What is the definition of Dissolution per USP?

According to the USP (United States Pharmacopeia), dissolution is defined as the process by which a solid substance enters into a solvent to yield a solution. It is a critical test for assessing the rate and extent of drug release from a solid dosage form.


What is the principle of disintegration test apparatus?

basic principal of dissolution run as per individuala monograph and know the % of active drugs in sample


Reason for taking900ml of water as disintegration medium in disintegration test?

Taking 900ml of water as the disintegration medium in a disintegration test is commonly used to simulate the conditions of the stomach where the dosage form is expected to disintegrate. This volume is considered sufficient to provide the necessary agitation and dissolution properties needed for the test. It also helps ensure reproducibility and accuracy in the disintegration test results.


The procedure indicates that the amount of time th test tube was kept in th boiling water bath should be minimized why was this necessary?

The procedure indicates that the amount of time the test tube was kept boiling in the water bath should be minimized. The water bath should never be allowed to boil dry.


What is a disintegration time apparatus?

For a drug to show maximum availability in the body it must be in solution form. So as a first step, the tablets that we take in, should break down to smaller particles or granules.This breaking up process is known as disintegration. disintegration is an important parameter of the tablet. It is determined with an apparatus described