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How you can synthesise procaine?

Updated: 8/11/2023
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Appu36

Lvl 1
14y ago

Best Answer

Try an acid catalyzed esterification of p-aminobenzoic acid with 2-diethylamino-ethanol. Use ~3.5 equivalents of sulfuric acid as the acid catalyst (note 2 of these will be used up to protonate nitrogens while the esterification takes place). reflux for ~2 hours, quench with sodium carbonate to mop up the acid afterwards, then recrystallize from a suitable solvent (maybe ethanol/water mix).

Note the above is just a guess and may need further refinement.

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16y ago
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Q: How you can synthesise procaine?
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