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Q: If the binding of the neurotransmitter to its receptor results in the opening of N a plus channels it will cause the membrane of the post synaptic neuron to .?
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What does the neurotransmitter bind to after it moves across the synaptic cleft?

It becomes reabsorbed by the sending membrane.


What are the principles of synaptic transmission?

Calcium ions enter the presynaptic neuron resulting in the release of neurotransmitter from the per-synaptic membrane. The neurotransmitter diffuses across the synaptic cleft, fusing with the receptors of the post-synaptic membrane. This changes the sodium channels to open and sodium ions will to flow into the post-synaptic neuron, depolarizing the post-synaptic membrane. This initiates an action potential. After the post-synaptic neuron has been affected, the neurotransmitter is removed by a type of enzyme called cholinesterase. The inactivated neurotransmitter then returns to the pre-synaptic neuron.


When a neuron responds to a particular neurotransmitter by opening gated ion channels the neurotransmitter is serving as which part of the signal pathway?

Signal Molecule Synaptic transmission is when it moves across the synaptic gap, and it then just binds to the receptor on the other side.


What happens after nerve signal reaches a synaptic knob?

In general, action potentials that reach the synaptic knobs cause a neurotransmitter to be released into the synaptic cleft. The arrival of the action potential opens voltage-sensitive calcium channels in the presynaptic membrane.


What ion triggers the release of a neurotransmitter at the presynaptic membrane?

Calcium triggers synaptic vesicles to discharge the neurotransmitter into the synaptic cleft.


How do nerves impulse's across the synapse?

Most neurons have a chemical synapse, which is to say that a substance called a neurotransmitter is released from the first neuron (called pre-synaptic) to the next neuron called (post-synaptic). How is the release triggered? When an action potential reaches the terminus (end of the axon) there are specialized calcium channels that are opened (voltage-gated). The calcium bind so the inner membrane and triggers the release of small membrane bound vesicles which spill out their contents of neurotransmitter into the synaptic cleft. The neurotransmitter binds to specific receptors on the post-synaptic membrane and that causes the action potential to propagate on (or for the neurotransmitter to cause an action like a muscle contraction).


What forms receptor sites on the post synaptic cell membrane?

your DNA.


What causes the synaptic delay?

The cause of synaptic delay is attributed mainly to the time needed for the synaptic vesicles to release neurotransmitter into the synaptic cleft. While it can be considered a combination of binding to the presynaptic membrane (which is relatively a transient process) and subsequent exocytosis of the neurotransmitter, the main factor is release. Additionally, it does take a very short period of time for the neurotransmitter to diffuse across the synaptic cleft and bind to to its receptors on the post-synaptic membrane.


What does the synaptic knobs of the presynaptic neuron contain synaptic vesicles loaded with?

To provide energy for the re-combination of Choline and ethanoic acid, to form Acetylcholine. Acetylcholine is used as a neurotransmitter, and gets broken down after its reached the sodium channels' receptors on the post-synaptic membrane by acetylcholinease.


How do nerve impulses travel across the synapse?

By a chemical released by an axon.


A concept map demonstrating the events of neurotransmitter?

Action potential reaches the action terminal of a nerve cell. This triggers calcium gated ion channels in the axon terminal to open, calcium rushes in. This causes vesicles filled with neurotransmitter to fuse to the membrane and dump the neurotransmitter into the synaptic cleft by exocytosis.


Describe how synapses work?

The action potential reaches the pre synaptic area, which opens a voltage sensitive Calcium ion gate, allowing calcium ions to move in via diffusion along an electrochemical gradient. The period of refraction (repolarisation) closes this gate. The increased conc. of Calcium ions pushes vesicles with neurotransmitter to the presynaptic membrane, where they fuse and exocytosis causes the neurotransmitter to be released across the synaptic cleft. The NT binds to a receptor which opens Na+ channels on the postsynaptic membrane, allowing depolarisation due to Na+ diffusion which continues the action potential across the other neurone. The neurotransmitters are broken down by enzymes or are reabsorbed by endocytosis into the presynaptic cleft, using energy from ATP.