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Not necessarily. ANA is a sensitive test for SLE (97% of people with SLE will have a +ANA test) but it is not specific, since ANA can be present in a number of other diseases as well as in some people with no disease. Therefore a + ANA test should be followed up by anti-dsDNA and anti-Smith which are markers specific to lupus.

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Q: If you are ANA positive and have high globulin level in the blood does that mean you have Lupus?
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