If you snort oxycodone how long is it detectable in urine screens?

Answer 1

2-4 days...please continue reading

Metabolism and Elimination

A high portion of oxycodone is N-dealkylated to noroxycodone during first-pass metabolism.

Oxymorphone, is formed by the O-demethylation of oxycodone. The metabolism of oxycodone

to oxymorphone is catalyzed by CYP2D6. Free and conjugated noroxycodone, free and

conjugated oxycodone, and oxymorphone are excreted in human urine following a single oral

dose of oxycodone. Approximately 8% to 14% of the dose is excreted as free oxycodone over 24

hours after administration. Following a single, oral dose of oxycodone, the mean ± SD

elimination half-life is 3.51 ± 1.43 hours.

Acetaminophen is metabolized in the liver via cytochrome P450 microsomal enzyme. About

80% to 85% of the acetaminophen in the body is conjugated principally with glucuronic acid and

to a lesser extent with sulfuric acid and cysteine. After hepatic conjugation, 90% to 100% of the

drug is recovered in the urine within the first day.

About 4% of acetaminophen is metabolized via cytochrome P450 oxidase to a toxic metabolite

which is further detoxified by conjugation with glutathione, present in a fixed amount. It is

believed that the toxic metabolite NAPQI (N acetyl-p-benzoquinoneimine, Nacetylimidoquinone)

is responsible for liver necrosis. High doses of acetaminophen may deplete

the glutathione stores so that inactivation of the toxic metabolite is decreased. At high doses, the

capacity of metabolic pathways for conjugation with glucuronic acid and sulfuric acid may be

exceeded, resulting in increased metabolism of acetaminophen by alternate pathways.

Absorption and Distribution - The mean absolute oral bioavailability of oxycodone in cancer

patients was reported to be about 87%. Oxycodone has been shown to be 45% bound to human

plasma proteins in vitro. The volume of distribution after intravenous administration is

211.9 ± 186.6 L.

Absorption of acetaminophen is rapid and almost complete from the GI tract after oral

administration. With overdosage, absorption is complete in 4 hours. Acetaminophen is relatively

uniformly distributed throughout most body fluids. Binding of the drug to plasma proteins is

Oxycodone and Acetaminophen Tablets USP Page 3 of 16

5 mg*/325, 7.5 mg*/325 mg, 7.5 mg*/500 mg Prescribing Information

and 10 mg*/325 mg

variable; only 20% to 50% may be bound at the concentrations encountered during acute

intoxication.

Laboratory Tests

Although oxycodone may cross-react with some drug urine tests, no available studies were found

which determined the duration of detectability of oxycodone in urine drug screens. However,

based on pharmacokinetic data, the approximate duration of detectability for a single dose of

oxycodone is roughly estimated to be one to two days following drug exposure.

Urine testing for opiates may be performed to determine illicit drug use and for medical reasons

such as evaluation of patients with altered states of consciousness or monitoring efficacy of drug

rehabilitation efforts. The preliminary identification of opiates in urine involves the use of an

immunoassay screening and thin-layer chromatography (TLC). Gas chromatography/mass

spectrometry (GC/MS) may be utilized as a third-stage identification step in the medical

investigational sequence for opiate testing after immunoassay and TLC. The identities of 6-keto

opiates (e.g., oxycodone) can further be differentiated by the analysis of their methoximetrimethylsilyl

(MO-TMS) derivative.

Interactions with Alcohol and Drugs of Abuse

Oxycodone may be expected to have additive effects when used in conjunction with alcohol,

other opioids, or illicit drugs that cause central nervous system depression.

OVERDOSAGE

Signs and Symptoms

Serious overdose with oxycodone and acetaminophen tablets is characterized by signs and

symptoms of opioid and acetaminophen overdose. Oxycodone overdosage can be manifested by

respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes

respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle

flaccidity, cold and clammy skin, pupillary constriction (pupils may be dilated in the setting of

hypoxia), and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory

collapse, cardiac arrest and death may occur.

In acute acetaminophen overdosage, dose-dependent, potentially fatal hepatic necrosis is the

most serious adverse effect. Renal tubular necrosis, hypoglycemic coma and thrombocytopenia

may also occur.

In adults, hepatic toxicity has rarely been reported with acute overdoses of less than 10

grams and fatalities with less than 15 grams. Plasma acetaminophen levels > 300 mcg/mL at

4 hours post-ingestion were associated with hepatic damage in 90% of patients; minimal

hepatic damage is anticipated if plasma levels at 4 hours are < 120 mcg/mL or < 30 mcg/mL

at 12 hours after ingestion.

Importantly, young children seem to be more resistant than adults to the hepatotoxic effect of an

acetaminophen overdose. Despite this, the measures outlined below should be initiated in any

adult or child suspected of having ingested an acetaminophen overdose.

Early symptoms following a potentially hepatotoxic overdose may include: nausea, vomiting,

diaphoresis and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be

apparent until 48 to 72 hours post-ingestion.

Answer 2

it depeneds on the type of drug-test given. oxycodone does not show up on a normal 5-panel drug-test.