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Importance of ninhydrin test in clinical or research laboratory?
Wiki User
∙ 15y ago
Approximately 5% of patients with cervical dystonia receiving repeated botulinum neurotoxin A (BoNT/A) injections develop secondary loss of treatment benefit. Currently available tests to directly detect neutralizing BoNT/A antibodies (BoNT/A-AB) are either expensive or time consuming. To establish a simple, clinically useful test for antibody detection, we adapted the ninhydrin sweat test (NST). Eighteen dystonic patients with secondary nonresponse and clinically suspected BoNT/A-AB formation were tested for BoNT/A-AB in the mouse diaphragm test (MDT). In addition, the size of the anhidrotic area was determined by the NST 21 days after an intradermal dose of 10 U Dysport into the hypothenar region of the left palm. In nine patients, positive BoNT-AB titers were found in the MDT. There was a significant correlation between the BoNT/A-AB titers and the anhidrotic area (Spearman's rho = -0.9, P < 0.0001). Both tests provided comparably good results with respect to qualitative antibody detection. In the clinical situation of secondary nonresponse to BoNT/A therapy, the economical NST may be a helpful tool to detect neutralizing BoNT/A-AB.
© 2004 Movement Disorder Society
http://www3.interscience.wiley.com/journal/107632044/abstract?CRETRY=1&SRETRY=0
© 2004 Movement Disorder Society
Wiki User
∙ 15y ago
The ninhydrin test is important in clinical or research laboratories for detecting the presence of amino acids in samples. This test is commonly used to identify and quantify amino acids in biological samples, which is crucial for diagnosing certain metabolic disorders, monitoring nutritional status, and assessing protein levels in research studies. Additionally, the ninhydrin test is also used in forensic analysis to detect and visualize latent fingerprints left on surfaces.
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