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Trifluoroacetic acid (TFA) is a strong acid commonly used in organic synthesis for deprotection of compounds, such as removal of protecting groups from amino acids in peptide synthesis. TFA can also be used to catalyze reactions, such as esterifications and acetalizations. Additionally, TFA can participate in nucleophilic substitution reactions, particularly with electron-rich nucleophiles.
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Transformers Autobots happened in 2007.
The mechanism for tert-butyl ester deprotection using trifluoroacetic acid (TFA) involves the protonation of the oxygen atom in the ester group by TFA, leading to the cleavage of the tert-butyl group and formation of the corresponding carboxylic acid.
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