It's possible they have some sort of connection but it hasn't been established yet.
Yes, Isobel Flemming is related to Katherine Pierce in "The Vampire Diaries." Isobel is Elena Gilbert's biological mother, and Katherine was involved with both Stefan and Damon Salvatore in the past. Their connection unfolds throughout the series as their intertwined histories are revealed.
In the books they are not related at all as far as what was written. What was originally thought, was that Elena was the reincarnation of Katherine, but this was before anyone knew she was in the tomb underneath fells church
They were direct descendents of each other (most likely through Katerina's daughter).
Stefan Salvatore Damon Salvatore Katherine Pierce The tomb vampires Pearl Anna Isobel
"A vintner I knew in Avignon."
YES
Isobel
Jenna, John, Isobel
Mia Kirshner
The Vampire Diaries - 2009 Isobel 1-21 is rated/received certificates of: Brazil:14 (DVD rating) USA:TV-14
Isobel is played by Mia Kirshner.
Yes, Isobel had Elena when she was 16. Isobel had run away from her home and Elena's adoptive father was a doctor. Isobel was about to give birth and after she did, she disappeared. The Gilbert's then wrote their own names on Elena's birth certificate.
yes, she was researching mystic falls and its vampire lore. she wanted to become a vampire so she went to damon and he turnt her. alaric (isobels husband) caught damon killing her but foundout later in the series that she got turnt. isobel is elena's mother and john gilbert is her father but elena hates him