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Yes, the EGR *system* could factor in to misfires...

... Along with a range of other culprits.

The check engine codes would be a good place to find out specifically what is going on in your engine.

See "Related Questions" below for more about the EGR/DPFE system that relates to a 401 diagnostic code, along with check engine light background

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Q: In a 2002 Windstar could an Egr valve cause one cylinder to misfire?
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