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A drug that is used to treat AIDS by blocking the production of an enzyme?
Protease inhibitor
What is protease inhibitor coctail?
A protease is an enzyme that cleaves a protein molecule. There are many such enzymes with specific functions to either activate protein precursor molecules (activase) or to deactivate proteins that have served their purpose (deactivase) and are no longer necessary. These processes are regulated by protease inhibitors, which, as the name implies, inhibit, or slow down, the activation or deactivation processes. There are many such activase-deactivase-inhibitor systems involved, for example, in the blood coagulation (hemostasis) system to prevent either hemorrhage (blood doesn't quickly enough to prevent "bleeding out" after injury), or thrombosis (blood clots in an uncontrolled fashion, shutting off circulation).
What is the role of PMSF in protein extraction?
PMSF is a protease inhibitor. During the protein extraction, the proteases present in the cell lysate may digest the disered proteins, to prevent this PMSF is added!
What effect would you expect AZT to have on the number of T cells in an HIV-infected person's blood and immune system overall?
AZT (azidothymidine) is a nucleoside reverse transcriptase inhibitor commonly used in the treatment of HIV infection. It works by inhibiting the replication of the virus in infected cells. Consequently, AZT treatment can lead to an increase in the number of T cells in an HIV-infected person's blood. This occurs as the virus's replication is suppressed, allowing the immune system to recover and produce more T cells. Therefore, AZT can have a beneficial effect in restoring and strengthening the immune system of HIV-infected individuals.
What is the formula for protease?
Protease is an enzyme. It is essentially a protein. Protease is not a compound and therefore its formula cannot be given out. Protease are a class of enzymes involved in digesting proteins. The basic mode of action can be described as: Protein + Protease -----> Digested protein + protease Since enzymes do not react in a biochemical reaction (they are merely catalysis), protease appears on both sides of the reaction shown above
What is Indinavin?
Indinavin is Human Immunodeficiency Virus (HIV) protease inhibitor.
What is in the FBS that inhibits the trypsin?
Serum protease inhibitor alpha-1-antitrypsin
A drug that is used to treat AIDS by blocking the production of an enzyme?
Protease inhibitor
Alpha 1-antitrypsin role in coagulation?
Alph-1-antitrypsin, produced in the liver, is a protease inhibitor. It inhibits Factor XIa, thrombin, kallikrein, plasmin, and tPA in the coagulation pathway. It is the major inhibitor of FXIa.
Will calcium chloride and potassium phosphate precipitate?
yes it will precipitate DNA if your lysing nuclei; add benzamidine hydrochloride though as a protease inhibitor.
What is a Protease Paunch?
"Protease Paunch" is an effect that occurs with some people who are taking a protease inhibitor drug as part of an anti-retroviral therapy to treat HIV. Protease inhibitors are widely used as part of a drug regimen to treat HIV, and many people taking the medicines have noticed a bulge or distended abdomen. In it's most severe cases, it can appear as if the person is pregnant. This can happen to both men and women, but does not affect everyone who is taking a protease inhibitor. The "protease paunch" is a nickname given to the more general condition of lipodystrophy, which is a shifting of body fat in a person. In addition to the paunch, a deposit of fat on the top of the neck can occur, often called a 'buffalo hump', as well as fat can be lost from the facial area and arms and legs.
What is HIV protease inhibitor?
Protease inhibitors (PIs) are a class of medications used to treat or prevent infection by viruses, including HIV and Hepatitis C. PIs prevent viral replication by inhibiting the activity of HIV-1 protease, an enzyme used by the viruses to cleave nascent proteins for final assembly of new virons.
What is protease inhibitor coctail?
A protease is an enzyme that cleaves a protein molecule. There are many such enzymes with specific functions to either activate protein precursor molecules (activase) or to deactivate proteins that have served their purpose (deactivase) and are no longer necessary. These processes are regulated by protease inhibitors, which, as the name implies, inhibit, or slow down, the activation or deactivation processes. There are many such activase-deactivase-inhibitor systems involved, for example, in the blood coagulation (hemostasis) system to prevent either hemorrhage (blood doesn't quickly enough to prevent "bleeding out" after injury), or thrombosis (blood clots in an uncontrolled fashion, shutting off circulation).
How does AZT works?
3-azido-3-deoxythimidine, also known as Zidovudine or AZT, functions by interfering with DNA replication.The AZT molecule was first synthesized in 1964 by a chemist called Jerome Horwitz. AZT was originally synthesized in hoping to combat cancer cell growth. However, it was deemed ineffective, and was forgotten until the outbreak of AIDS.AZT is classified as a Nucleoside Reverse Transcriptase Inhibitor (NRTI). AZT replaces the nucleoside base Thymidine on the DNA strand when the synthesis of a new DNA strand occurs, during cellular division. This will terminate cellular division. This is why AZT is classified as a DNA chain terminating drug.HIV requires the host cell's DNA in order to replicate itself, and without the DNA strand fully functioning, HIV cannot replicate, and thus slowing down the reproduction of HIV.
How AZT work?
3-azido-3-deoxythimidine, also known as Zidovudine or AZT, functions by interfering with DNA replication.The AZT molecule was first synthesized in 1964 by a chemist called Jerome Horwitz. AZT was originally synthesized in hoping to combat cancer cell growth. However, it was deemed ineffective, and was forgotten until the outbreak of AIDS.AZT is classified as a Nucleoside Reverse Transcriptase Inhibitor (NRTI). AZT replaces the nucleoside base Thymidine on the DNA strand when the synthesis of a new DNA strand occurs, during cellular division. This will terminate cellular division. This is why AZT is classified as a DNA chain terminating drug.HIV requires the host cell's DNA in order to replicate itself, and without the DNA strand fully functioning, HIV cannot replicate, and thus slowing down the reproduction of HIV.
What is the role of PMSF in protein extraction?
PMSF is a protease inhibitor. During the protein extraction, the proteases present in the cell lysate may digest the disered proteins, to prevent this PMSF is added!
What is pepstatin?
Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases or serine proteases. Solublized Beta-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources. Pepstatin A is thought to inhibit by a collected-substrate inhibition mechanism.
