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"Protease Paunch" is an effect that occurs with some people who are taking a protease inhibitor drug as part of an anti-retroviral therapy to treat HIV. Protease inhibitors are widely used as part of a drug regimen to treat HIV, and many people taking the medicines have noticed a bulge or distended abdomen. In it's most severe cases, it can appear as if the person is pregnant. This can happen to both men and women, but does not affect everyone who is taking a protease inhibitor. The "protease paunch" is a nickname given to the more general condition of lipodystrophy, which is a shifting of body fat in a person. In addition to the paunch, a deposit of fat on the top of the neck can occur, often called a 'buffalo hump', as well as fat can be lost from the facial area and arms and legs.

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Q: What is a Protease Paunch?
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