Is Doctor Doom the most delusional super villain in marvel and literature believing he's flawless the smartest individual and all problems of his are Mr Fantastic's fault?

Yes.

Of course, there have been other supremely confident (certifiably insane) super-villains in comic book history.
Most of the super villains tend to be delusional, including Doctor Doom of the Marvel comics and literature. He does seem to believe he is flawless and the smartest person. He does blame Mr. Fantastic for his problems, so that is why they are enemies. He would probably rank very high in the most delusional super villains.