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Yes, both have Pseudophedrine as one of the active ingredients, so you will be taking more of it than recommended if you combine both.

The regular Zyrtec is just 10mg of Cetirizine. That should be OK to take with the advil cold and sinus but I would check with a doctor or pharmacist on the D versions of Claritin or Zyrtec with it.

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Q: Is advil cold and sinus and Zyrtec d the same kind of medicine?
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