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In general, yes, it is safe. However, you will want to take extra precautions, especially if you are traveling alone.

1) Mononucleosis is known as the "kissing disease" but can be transmitted via other means. Airports and airplanes can be hotbeds for spreading infectious disease. Be sure to protect others around you even more vigilantly than normal (when sneezing/coughing or when the stewardess takes your trash that may have your fluids for example).

2) Your spleen is typically enlarged when you have mononucleosis and strenuous activity such as heavy lifting can lead to rupture. As humbling it may be, don't take risks with lifting baggage, even for short distances or heights. Ask someone to assist you with checking and claiming bags and using the overhead compartments.

3) Make sure you're up for it. Mononucleosis can be extremely deliberating, making even the most menial tasks difficult. Travel of any sort is stressful and will increase substantially with mononucleosis. Weigh your symptoms vs the purpose of your travel. Don't forget that your illness may interfere with your plans once your reach your destination and consider whether the making the trip is worth the effort in the first place.

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Q: Is airline travel safe with Mononucleosis as long as there is no fever?
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