0
Is blood transfusion safe with alpha thalassemia traits after delivery?
Wiki User
∙ 14y agoWant this question answered?
Be notified when an answer is posted
Add your answer:
Earn +20 pts
Can minor thalassemia carrier and alpha marry?
Yes, A "carrier" of alpha thalassemia and of beta thalassemia can marry, but not to someone with any hemoglobinopathy. Prof. Kornfeld Pal
Are there other names for Thalassemia disease?
Alpha thalassemia silent carrierAlpha thalassemia minor, also called alpha thalassemia traitHemoglobin H diseaseAlpha thalassemia major, also called hydrops fetalisBeta thalassemia minor, also called beta thalassemia traitBeta thalassemia intermediaBeta thalassemia major, also called Cooley's anemia or beta-zero (ß0) thalassemiaBeta-plus (ß+) thalassemiaMediterranean anemia
Can thalassemia carrier and alpha marry?
yes
Will the child be free from thalassemia if you are alpha and father is beta thalassemia trait?
have seen one of my friends sister had kid and all normal no complications...not thalassemia either.........beta and alpha i think there is 25% normal chance
What are the chances of hydrops fetalis recurring if only the mother has alpha thalassemia trait?
It is unlikely.
Can you have both alpha thalassemia and beta thalassemia?
Of coare yes. You can get any hemoglobinopathy from a parent without any connection to other hemoglobinopathy (or any other hereditary disease) from the other parent. Prof. Kornfeld Pal
What does thallassemia mean?
Thalassemia describes a group of inherited disorders characterized by reduced or absent amounts of hemoglobin, the oxygen-carrying protein inside the red blood cells. There are two basic groups of thalassemia disorders: alpha thalassemia and beta thalassemia. These conditions cause varying degrees of anemia, which can range from insignificant to life threatening. Go to: http://medical-dictionary.thefreedictionary.com/Thallassemia
Can thalassemia develop at the age of 20 years?
Very unlikely. Thalassemia is an inherited disease, affected persons are born with the genetic disorders. However, silent carriers (Alpha Thalassemia, 1 gene defect) or Beta Thalassemia Trait (1 gene defect), do not have significiant symptoms. Consequently, if this person did not have any relevant blood tests till the age of 20, he/she might no be aware of having the condition. That's only a hypothetical suggestion.
What is HbH disease?
Normal Red Blood cells are made up of 2 alpha and 2 beta protein chains.In alpha thalassemia, there's a qualitative decrease in the number of red blood cells (RBC) that have these 2alpha and 2 beta.Since the Alpha protein is made up of 2 genes on Chromosome 16,there are 4 possible alleles.So there's 4 type of Genotypes. 1) A-/AA 2) AA/-- or A-/A- 3) A-/-- 4) --/-- HBH refers to the type of Haemoglobin found in 3) A-/-- in alpha thalassemia whereby 3 out of 4 of the allele is lost due to a deletion mutation on chr 16.
What is the treatment for beta thalassemia?
Thalassemias, (alpha, beta, and their subdivisions) are genetic disorders, affecting the number and the oxygen/carbon dioxide carrying ability of the erythrocytes. The later is due to defective heamoglobin structure. The disease's severity depends on the severity of the defect, and the treatment likewise. For example, defect in Alpha thalassemia silent is very mild, therefore treatment might not even be necessary. Treatments for the more severe types include blood transfusion, iron chelation, vitamin and folic acid supplementation, surgical removal of the spleen (in Alpha thalassemia major). Researches into new treatments include donor blood and marrow stem cell transplantation, gene therapy, and activation of fetal haemoglobin.
Why does symptoms of beta thalassemia doesn't appear at birth?
Symptoms of beta thalassemia major or Cooley's anemia don't appear at birth because babies still have what is known as the fetal hemoglobin, which consists of two alpha chains and two delta chains, but the baby has no beta chains and therefore protected from the disorder. The baby will eventually develop the beta chains though.
Thalassemia?
DefinitionThalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells, which leads to anemia.See also:Hemolytic anemiaSickle cell diseaseAlternative NamesMediterranean anemia; Cooley's anemia; Beta thalassemia; Alpha thalassemiaCauses, incidence, and risk factorsHemoglobin is made of two proteins: Alpha globin and beta globin. Thalassemia occurs when there is a defect in a gene that helps control production of one of these proteins.There are two main types of thalassemia:Alpha thalassemia occurs when a gene or genes related to the alpha globin protein are missing or changed (mutated).Beta thalassemia occurs when similar gene defects affect production of the beta globin protein.Alpha thalassemias occur most commonly in persons from southeast Asia, the Middle East, China, and in those of African descent.Beta thalassemias occur in persons of Mediterranean origin, and to a lesser extent, Chinese, other Asians, and African Americans.There are many forms of thalassemia. Each type has many different subtypes. Both alpha and beta thalassemia include the following two forms:Thalassemia majorThalassemia minorYou must inherit the defective gene from both parents to develop thalassemia major.Thalassemia minor occurs if you receive the defective gene from only one parent. Persons with this form of the disorder are carriers of the disease and usually do not have symptoms.Beta thalassemia major is also called Cooley's anemia.Risk factors for thalassemia include:Asian, Chinese, Mediterranean, or African American ethnicityFamily history of the disorderSymptomsThe most severe form of alpha thalassemia major causes stillbirth (death of the unborn baby during birth or the late stages of pregnancy).Children born with thalessemia major (Cooley's anemia) are normal at birth, but develop severe anemia during the first year of life.Other symptoms can include:Bone deformities in the faceFatigueGrowth failureShortness of breathYellow skin (jaundice)Persons with the minor form of alpha and beta thalassemia have small red blood cells (which are identified by looking at their red blood cells under a microscope), but no symptoms.Signs and testsA physical exam may reveal a swollen (enlarged) spleen.A blood sample will be taken and sent to a laboratory for examination.Red blood cells will appear small and abnormally shaped when looked at under a microscope.A complete blood count (CBC) reveals anemia.A test called hemoglobin electrophoresisshows the presence of an abnormal form of hemoglobin.A test called mutational analysis can help detect alpha thalassemia that cannot be seen with hemoglobin electrophoresis.TreatmentTreatment for thalassemia major often involves regular blood transfusions and folate supplements.If you receive blood transfusions, you should not take iron supplements. Doing so can cause a high amount of iron to build up in the body, which can be harmful.Persons who receive significant numbers of blood transfusions need a treatment called chelation therapy to remove excess iron from the body.Bone marrow transplant may help treat the disease in some patients, especially children.Expectations (prognosis)Severe thalassemia can cause early death due to heart failure a, usually between ages 20 and 30. Frequent blood transfusions with therapy to remove iron from the body helps improve the outcome.Less severe forms of thalassemia usually do not result in a shorter life span.ComplicationsUntreated, thalassemia major leads to heart failure and liver problems, and makes a person more likely to develop infections.Blood transfusions can help control some symptoms, but may result in too much iron which can damage the heart, liver, and endocrine system.Calling your health care providerCall for an appointment with your health care provider if:You or your child has symptoms of thalassemiaYou are being treated for the disorder and new symptoms developPreventionGenetic counseling and prenatal screening may be available to those with a family history of this condition who are planning to have children.ReferencesGiardina PJ, Forget BG. Thalassemia syndromes. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 41.DeBaun MR, Vichinsky E. Hemoglobinopathies. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 462.
