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Endochondral ossification is the process by which the embryonic cartilaginous model of most bones contributes to longitudinal growth and is gradually replaced by bone. During endochondral ossification, chondrocytes proliferate, undergo hypertrophy and die; the cartilage extracellular matrix they construct is then invaded by blood vessels, osteoclasts, bone marrow cells and osteoblasts, the last of which deposit bone on remnants of cartilage matrix. The sequential changes in chondrocyte behaviour are tightly regulated by both systemic factors and locally secreted factors, which act on receptors to effect intracellular signalling and activation of chondrocyte-selective transcription factors. Systemic factors that regulate the behaviour of chondrocytes in growth cartilage include growth hormone and thyroid hormone, and the local secreted factors include Indian hedgehog, parathyroid hormone-related peptide, fibroblast growth factors and components of the cartilage extracellular matrix. Transcription factors that play critical roles in regulation of chondrocyte gene expression under the control of these extracellular factors include Runx2, Sox9 and MEF2C. The invasion of cartilage matrix by the ossification front is dependent on its resorption by members of the matrix metalloproteinase family, as well as the presence of blood vessels and bone-resorbing osteoclasts. This review, which places an emphasis on recent advances and current areas of debate, discusses the complex interactions between cell types and signalling pathways that govern endochondral ossification.
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∙ 11y ago
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∙ 15y agoThe embryonic skeleton is cartilage.
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∙ 14y agohyaline cartilage
Wiki User
∙ 11y agoHyaline Cartilage
Hyaline Cartilage
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∙ 12y agofibrocartilage and hyaline cartilage.
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∙ 11y agoNo ldea
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Forms the larynx the coastal cartilages of the ribs and the embryonic skeleton?
Osseous tissue
Forms embryonic skeleton and the surface of the bones at the joints reinforces the trachea?
Hyaline cartilage
Which type of connective tissue is found in the trachea and between the ribs and sternum?
The hyaline cartilage forms most of the embryonic skeleton. It also forms coastal cartilages of ribs, cartilages of the nose, trachea and larynx.
What are structures that develop from the same embryonic tissues but have different mature forms?
Homologous Structures.I Hope This Helped.
During embryonic development cells specialize to form what?
a group of specialized cells forms tissue, a group of tissue forms an organ
Forms the larynx the coastal cartilages of the ribs and the embryonic skeleton?
Osseous tissue
What connective tissue forms the larynx and the coastal cartilages of the ribs and embryonic skeleton?
hyaline cartilage
Forms embryonic skeleton and the surface of the bones at the joints reinforces the trachea?
Hyaline cartilage
What does the embryonic skeleton consist of?
Hyaline Cartilage
Which layer of embryonic tissue forms the lining of the digestive tract?
endoderm
What is the embryonic origin of the cerebral hemispheres?
The embryonic origin of the cerebral hemispheres is from the neural ectoderm. The neural ectoderm is an area of tissue that forms in the center of the developing blastocyst.
Type of tissue that forms the bony skeleton?
Osseous
What skeleton forms the main trunk of the body?
skul.....
What are two forms of the word bone?
born skeleton
Which connective tissue forms the bony skeleton?
Osseous types of connective tissue forms the bony skeleton. Adipose is the types of connective tissues composes dermis of skin.
Which type of connective tissue is found in the trachea and between the ribs and sternum?
The hyaline cartilage forms most of the embryonic skeleton. It also forms coastal cartilages of ribs, cartilages of the nose, trachea and larynx.
What are structures that develop from the same embryonic tissues but have different mature forms?
Homologous Structures.I Hope This Helped.
