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The cells of the Dieffenbachiaplant contain needle-shaped calcium oxalate crystals called raphides. If a leaf is chewed, these crystals can cause a temporary burning sensation and erythema. In rare cases, edema of tissues exposed to the plant have been reported. Mastication and ingestion generally result in only mild symptoms.[2] With both children and pets, contact with dieffenbachia (typically from chewing) can cause a host of unpleasant symptoms, including oral irritation, excessive drooling, and localized swelling.[3] However, these effects are rarely life-threatening. In most cases, symptoms are mild, and can be successfully treated with analgesic agents,[4] antihistamines,[5] or medical charcoal.[6] Gastric evacuation or lavage is "seldom"[6] indicated.[4] Jennifer S. Boyle, MD, PharmD, and Christopher P Holstege, MD, note that, "In a large retrospective study of 188 patients with plant oxalate exposure, all cases were determined to be minor and all resolved with minor or no treatment". [4] They also note that, "In patients with exposure to toxic plants, 70% are children younger than 5 years".

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