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I have taken the two together in the past with no problems. Also, it does not appear to state anywhere in the prescription information that melatonin will interact with wellbutrin.

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15y ago
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12y ago

Yes, I asked my doctor this question and he said it would be fine. I'm on 150mg of Wellbutrin daily and I take Melatonin at night thru the week. I haven't had any problems.

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Wiki User

13y ago

My doctor told me yes.

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Wiki User

11y ago

yes it is fine...

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Q: Can you take melatonin with Wellbutrin?
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