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There may be an interaction between dimenhydrinate and any of the following:

  • alcohol
  • anticholinergics (e.g., benztropine, oxybutynin)
  • antihistamines (e.g., diphenhydramine, chlorpheniramine)
  • barbiturates (e.g., phenobarbital, butalbital)
  • benzodiazepines (e.g., diazepam, lorazepam, oxazepam)
  • muscle relaxants (e.g., cyclobenzaprine)
  • opioid medications (e.g., codeine, morphine)
  • other medications that cause drowsiness (e.g., chlorpromazine, gabapentin, loxapine, mirtazapine, quetiapine, zopiclone, droperidol)
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Q: Is it okay to take Gravol 5 hours after you have taken a night time cold medicine?
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