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Probably, but why take these two together?

In other words, on my Ritalin information sheet, it says not to take zoloft (that's sertraline, right?) with it. Yet, my doctor prescribed it and apparently, doctors (generally) seem to love to prescribe zoloft with stimulants. But many of us have found that zoloft cancels the uplifting effects (for example, in the case of Ritalin with zoloft).

I have never tried zoloft with Provigil, which is not a stimulant per se. Per my experience, I can't see why you would need an anti-depressant with Provigil, which for me, was very mood uplifting. But that's me, and I am more in the anxiety and ADD/HD category than depression.

Upshot: I will never try zoloft again, period!. But if you really love zoloft, maybe try the combo after reading the contraindications first, and/or asking a psy-doctor or neurologist.

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13y ago
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14y ago

In this case synthroid doesn't react with either provigil or zoloft. However provigil and zoloft do.

Provigil may decrease the metabolism of Zoloft. This can alter Zolofts intended use.The benefits of combined use of these two medications usually outweigh the risks. Timing and dosage play a factor in the interaction of the two. You should talk to your doctor if you have any concerns.

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Q: Is it safe to take Zoloft and focalin at the same time?
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