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One of the defining properties of a neurotransmitter is that is must be synthesized in the neuron. The brain does not synthesize methamphetamine. Methamphetamine is introduced exogenously and exerts its effects on a neurotranmitter system called the 'adrenergic system'. Methamphetamine also has a direct effect on dopamine transmission. The drug, like its parent structure (amphetamine) causes a release of dopamine through reuptake transporters (DATs), which have been modulated to reverse their normal function as a consequence of binding this drug. This rush of dopamine is what gives rise to many of the euphoric (hedonic) as well as addictive properties of this drug. So infact it is acting as an indirect neurotransmitter, but is not an endogenous (normally produced and supplied in the body) molecule.

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Q: Is it true that methampetamine hydro cloride is considered a brain transmitter?
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