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From a medical standpoint it is not uncommon for a combination of medications to use used to treat ADHD. A combination of Concerta (methylphenidate), Strattera (atomoxetine), and Wellbutrin (bupropion) is somewhat odd but not extreme. Both Concerta and Strattera are approved to treat ADHD, Wellbutrin is not although there is some evidence it can be helpful in people with ADHD, particularly those who fail to adequately respond to stimulants.

It is perfectly appropriate and fairly common for two medications to be used at one time, typically a stimulant like Concerta and either Strattera or Wellbutrin. It is not unheard of for two stimulants like Concerta and Adderall to be used together or for Strattera and Wellbutrin to be used together. Often adding either Strattera or Wellbutrin in a conventional stimulant like Concerta can provide better symptom control.

Concerta and Strattera have no significant drug interactions however both have some interaction with Wellbutrin, which may increase plasma concentrations of Strattera and there is a slight increase is seizure risk when combining Concerta with Wellbutrin. However the risk is very minor and people with no history of epilepsy are unlikely to have a problem. Risk of seizure when taking Wellbutrin is typically about 0.4%.

Simply put there is no medical reason all three medications can't be used at the same time although it is, as it always is, important to monitor for side effects. But using three medications is uncommon however doctors are able to prescribe unusual combinations of medication because some people require a more novel treatment.

As always if you have any concerns or side effects please tell your doctor. Do not increase, decrease, or stop medication without talking with your doctor.

Anecdotal answer

No. But if you really have a concern you should consult with the prescribing doctor. You could be on one of the medications until the others kick in. Or you could simply be taking a low dose of all 3. From the Wellbutrin (and not being a prescribing doctor) it's hard to tell what the direction is here... you could have been given the Wellbutrin to offset side effects, or to work with one or both of the other medications. Wellbutrin does have stimulant properties, more so than Strattera, however neither drug has stimulant effects like Concerta. If you are not feeling comfortable with these medications be sure to talk with your doctor. Only he can explain his reasoning or he may change the prescription altogether. As far as being a weird combination... no it's not.

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Q: Is it unusual to be prescribed Strattera Concerta and Wellbutrin for ADHD?
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