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Yes. Malonate is a competitive inhibitor because it is unreactive as dehydrogenation cannot occur. Malonate is in the cis form, whereas fumarate is in the trans form.
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How malonate inhibit the conversion of succinate to fumarate?
Malonate is a competitive inhibitor of succinate dehydrogenase, the enzyme responsible for converting succinate to fumarate in the citric acid cycle. Malonate resembles succinate and competes for the active site of succinate dehydrogenase. As a result, malonate binds to the enzyme and prevents succinate from binding, inhibiting the conversion of succinate to fumarate.
Differences between succinate and succinate malonate?
Malonate is a competitive inhibitor preventing the substrate succinate from binding to the enzyme. The structure of succinate is comparable to that of malonate but for the ability for malonate to bind to an enzyme but then cannot further act on it creating a nonproductive complex.
What statement best describes the function of a competitive inhibitor in an enzyme-catalyzed reaction?
Competitive inhibitor is a substance that competes directly with a normal substrate for an enzymatic-binding site of an enzyme. Such an inhibitor usually resembles the substrate to the extent that it specifically binds to the active site of the enzyme but differs from it so as to be unreactive and therefore there will be no catalytic reaction. Some examples are: methotrexate that is competitive inhibitor of dihydrofolate reductase, and malonate which structurally resembles succinate (that is converted to fumarate by succinate dehydrogenase during the citric acid cycle) but cannot be dehydrogenated.
What is microgynon ed and ferrous fumarate?
Microgynon Ed is a type of hormonal contraceptive typically given in the form of tablets. Ferrous fumarate is iron (II) fumarate and is taken to supplement your intake of iron.
How is synthesized?
Dimedone is synthesized from mesityl oxide and diethyl malonate .
How is dimedone synthesized?
Dimedone is synthesized from mesityl oxide and diethyl malonate .
Why ferrous ascorbate prefer instead of ferrous fumarate?
Ferrous ascorbate and ferrous fumarate are for different purposes. Ferrous fumarate is for the anemic patients those are deficient in iron while ferrous ascorbate helps retardation or prevention of Fe(II) oxidation.
Is formoterol fumarate a steroid?
yes its a steroid
What are the advantages and disadvantages of ferrous sulfate ferrous fumarate and ferrous gluconate?
Ferrous fumarate causes far less constipation and stomach irritation compared with ferrous sulfate. Ferrous gluconate is also less constipating, but still is more so than fumarate.
How much ferrous ascorbate is equivalent to 100 mg of elemental iron?
Molar mass of Fe-fumarate is 169.8 g/molAtomic mass of Fe is 55.81 mol of Fe-fumarate is 169.8 g; 55.8 g of that is Fe2+.So, 100 mg of Fe-fumarate will have 100x(55.8/169.8)=32.8 mg of elemental FeQuestion is on ferrous ascorbate but answer is on ferrous fumarate. Confused
Is Bosoprolol Fumarate Lodoz a diuretic?
yes is a diuretics
How Lambda max determined for quetiapine fumarate?
by injecting the sample in to a HPLC system having PDA detector or Scan the Quetiapine Fumarate sample solution in UV range.
