Yes. In fact, such is the brain's demand for oxygen that it requires 20% of your total oxygen supply. This explains why it is served by so many blood vessels.
The brain consumes 40% of the oxygen in your blood.
brain
In blood.
Asphyxiation - lack of Oxygen to the brain!
Carbohydrates and oxygen.
Because oxygen is used to burn glucose, the fuel preferred by the brain. At rest, you use about 20% of the oxygen you breathe to keep your brain running.
Einstein
Actually, no human being can go without oxygen for 4 minutes and be expected to live
The vital function that oxygen serves in the human body is respiration. Oxygen is needed for the lungs to function and for the proper functioning of other vital organs such as the heart and brain.
oxygen
In the blood, cells, and our lungs.
If by "shut down" you mean "die," then yes.