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Sickle Cell Anaemia is a single gene defect (Hb gene).
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∙ 15y ago
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What type of mutation causes sickle cell anemia substitution deletion insertion mutagen?
The type of mutation that causes a defect in the gene (causing sickle cell anaemia) is a substitution mutation.A single nucleotide substitution (A to T) in the β-globin gene causes the amino acid valine to replace glutamic acid. This changes the resulting protein, causing a haemoglobin with an abnormal shape to be created.
What is a genetic disorder that causes abnormal hemoglobin?
Sickle cell anemia causes sickle-shaped red blood cells. It is caused by a single base pair gene mutation.
What are survival values of sickle cell anemia?
A single copy of the gene results in a person who is unlikely to develop full-blown sickle-cell anaemia, but has a strong resistance to malaria.
In which hereditary disease does abnormal hemoglobin differ from normal hemoglobin by only a single amino acid?
Sickle-cell anemia
Which types of mutation causes sickle cell anemia?
No single mutation is responsible for this disease. It just happens by abnormality in the red blood cells. It affects the hemoglobin.
Could the same genetic condition that causes sickle cell anemia can also protect against any other diseases?
A single sickle-cell gene protects against malaria. Two sickle-cell genes produce sickle-cell disease.
Define a genetic mutation and state the types of genetic mutations?
Point mutation: single nucleotide is replaced with another. ex: sickle cell anemia.
How does a person with sickle-cell allele differ from a person with two sickle-cell alleles?
If a person has a single sickle cell allele they will have some sickles red blood cells, and some normal red blood cells. This is the origami purpose that this evolved for. If a person had a single sickle cell allele, they will be mostly resistant to malaria. This is why sickle cell anemia is most prevalent in areas of the world where malaria is common. However, if a person has two sickle cell anemia alleles, they will have ONLY sickled red blood cells. The "sickling" of the red blood cells is caused by a mutation in the protien that the gene codes for. That protein is hemoglobin, which carries oxygen through the blood. If a person has sickle cell anemia, parts of their body wil not get enough oxygen. They can pass out, loose sensation in the limb, or even die from it. In short, a person with two alleles is sick, and a person with one allele is not.
How is it possible for only some races to have certain diseases or deformities like Sickle-Cell Anemia for African-Americans and Head Lice for Caucasians?
Some diseases are the result of adaptations to an environment. As it turns out, Sickle Cell Anemia is an adaptation to Malaria. If a person has a single copy of the Sicke Cell gene, he or she is protected against Malaria. If he or she has NO copies of the gene, he or she will die if exposed to Malaria. If he or she has two copies of the gene he or she will die from Sickle Cell Anemia. Malaria was fatal to pretty much everyone. The genetic mutation allowed about half of the population of the region to live. Today, we no longer have the threat from Malaria so now Sickle Cell Anemia becomes the problem.
How is sickle cell anemia iherited?
Recessively, that means that both parents must be symptomless carriers then there is only a 1 in 4 chance that a given child will be born with the disease. Note: symptomless carriers have the strong advantage of being much more likely to survive malaria than "normals". Sickle cell disease is inherited through a single pair of genes (one gene from each parent), on chromosome 11. They must receive the gene from both parents in order to actually get sickle cell disease. If they receive one gene for sickle cell disease from one parent but a normal gene from another, they have "sickle cell trait." The genes that involve sickle cell control the production of hemoglobin (a protein) in red blood cells. Abnormal hemoglobin from sickle cell disease causes red blood cells to grow incorrectly. Persons with sickle cell trait are much more resistant to malaria (a common disease in Africa, where the gene originated) than persons having two normal genes. This makes the sickle cell gene very likely to persist in areas where malaria is endemic, like Africa.
The cause of sickle cell anemia is?
a child must inherit two copies of the defective gene in order to have a cystics fibrosis but when it come to sickle-cell anemia it is a disease passed down through families in which red blood cells from an abnormal sickle or crescent shape.Red blood cells carry oxygen to the body and are normally shaped like a disc so what causes sickle-cell anemia is the two copies that they get from both parents which gets passed down through families.
How many copies of an allele need to be present for someone to have cystic fibrosis?
Both cystic fibrosis and sickle cell anemia are single mutation diseases - one mutation in a single gene is enough to cause the disease. However, for cystic fibrosis both alleles of the gene must be mutated for the disease to develop. For sickle cell anemia, only one allele can carry the mutation and some signs of the disorder will be present. Having two alleles with the mutation causes much more significant disease.
