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I got an answer since I posted the question. According to my pharmacist, Mucinex D with pseudoephedrine is the equivalent according to my pharmacist. I tried it and it's working well. I use this to stave off sinus infections when I get allergic sinusitus. It's an extended release expectorant with nasal congestant.

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Q: Is there a non-prescription drug equivalent to Entex PSE?
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What are the generics for Entex PSE?

Each Entex PSE tab contained: * 120 mg pseudoephedrine hydrochloride * 600 mg guaifenesin in a scored, long-acting tablet. Since that formulation is not available from Dura (manufacturer) any longer, you can do the following: 600 mg Mucinex Guaifenesin Extended-Release Tablets (Adams Laboratories, Inc.) taken at the rate of one tablet every 12 hours would be equivalent to the guaifenesin content of one Entex PSE tablet taken at the same rate. Since the Entex PSE is "long-acting" and Mucinex is "Extended-Release," I would argue the rates are equivalent. 30 mg Non-Drowsy Sudafed (Warner-Lambert Consumer Healthcare) taken at the rate of two tablets every 6 hours would be the equivalent of the pseudoephedrine HCl content of one Entex PSE tablet taken at one every 12 hours. The Sudafed is not a time-release formula, so you should expect to take the 30 mg tablets more frequently in the smaller dosage (30 mg). You will have to sign the registry at the pharmacist counter in order to purchase the Sudafed, but as long as you do not have a "Meth-lab" in your home, you can probably feel safe in registering your purchases. I am not aware of time-release formulations of Pseudoephedrine HCl, but you should be cautious of additional ingredients such formulations may contain. If you were accustomed to breaking the scored Extex PSE, you should be aware that Mucinex tablets are not to be "broken." There are other brands of Guaifenesin available over-the-counter, so you could adjust to a lower dosage by purchasing one in a lower strength. I have found 400 mg guaifenesin, but I don't recall 300 mg tablets. Beware of Guaifenesin containing additional ingredients which may not be advisable in combination with Sudafed. If you are looking for a replacement for Entex PSE, stick to the ingredients of Entex PSE --- that makes sense, huh? In any event, do not exceed the manufacturers' recommended dosages of either and be watchful of potential side-effects of both drugs. It is likely the side effects of the "roll your own" version would be the same as that of the Dura tablets you were taking, but there is no guarantee of that.


Can you take Entex and Robitussin DM together?

ENTEX PSE AND ROBITUSSIN DM are both cough syrup that share one ingredient: GUAIFENESIN. Guaifenesin is an expectorant, which loosens up the phlegm (mucus) in your chest, so that when you cough, it is a productive cough. While ROBITUSSIN DM also has a cough ingedient, that helps a nagging cough, ENTEX PSE has another ingredient (Sudafed) to help dry up your dripping stuffy nose. You should probably pick one or the other, however taking both together would not be dangerous. Just don't go over the maximum intake of guaifenesin for a 24 hr. period.


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You need your ID to purchase certain OTC drugs such as cough and cold medicines that include pseudoephedrine (PSE). PSE is a drug that treats nasal congestion (clears your nose) but it has been abused by people who use it make crystal meth. As a result, there are limitations in buying the drug including how much per day and month one can buy PSE and that a customer has to provide identification so the stores can document that person.


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