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Some cancer therapy prodrugs include:
cyclophosphamide
capecitabine
dacarbazine - is ONLY converted to active form by the liver
5-Fluorouracil
etoposide phosphate
gemcitabine
irinotecan - therapy relies on strongly active metabolites in addition to an active parent compound.
These must be metabolized into an active metabolite in order to kill a cancer cell. Sometimes this occurs in the liver, but most of the above medications can be activated inside any cancer or normal cell also, so the expose their full anti-cancer effect locally, and hopefully avoid as many body-wide side effects. No drug is 100% safe.
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