MGUS - monoclonal gamapathy of undetermined sinifigance or WM Waldenstrom's Macroglobulinemia?
This isnt a meaningful question you might as well ask red or white?
What was the name of the first FDA approved Monoclonal antibody for the treatment of rheumatoid arthritis?
During pregnancy a hormone called HCG (Human Chorionic Gonadotrophin is release,this hormone is detected by a special chemical called Monoclonal antibodies what this monoclonal antibodies does is attaches itself to the to the HCG hormone forming a colored band which indicates whether or not a woman is pregnant.
Yes, Herceptin is a drug used in certain form of breast cancer which overexpresses the HER-2 protein, enabling angiogenesis and rapid tumour growth. Herceptin is the trade name for monoclonal antibodies against the HER-2 receptor which block these, limiting their function and improving patient prognosis. There are other examples to, monoclonal antibodies against IgE antibody to prevent type 1 hypersentivity e.g. peanut allergy.
In criminology, monoclonal antibiodies are useful in distinguishing adult serum stains from those of a fetus's or newborn's serum in cases of illegal abortion or infanticide. (A new method uses sensitive detection of α-fetoprotein AFP in the stains.) In wildlife magaement it can be used to determine and map animals with diseases. An example is rabies. Monoclonal antibiodies can be used in archeology to identify archeological disoveries.
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope. Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify…
Polyclonal antibody recognizes several epitopes on the target protein while monoclonal antibody recognizes only single epitope, hence monoclonal antibodies are more specific than polyclonal antibodies. However, sometimes MAbs are not able to precipitate the antigen because the epitope might need to be exposed on the surface of the antigen to be recognized by the antibody. Since some of the epitope might be hidden and it's a single epitope that is recognized by the monoclonal antibody…
Why polyclonal antibody solution is able to precipitate its antigen protein whereas monlclonal antibody solution has hard time to do so?
Polyclonal antibody recognizes several epitopes on the target protein while monoclonal antibody recognizes only single epitope. Sometimes, monoclonal antibodies are not able to precipitate the antigen because the epitope might need to be exposed on the surface of the antigen to be recognized by the antibody. Since the epitope might be hidden and it's a single epitope that is recognized by the monoclonal antibody, the propability of the antibody to reconize the epitope is lower…
These are tumor cells that arose from a single lymphocyte or plasma cell. The kappa light chain is a piece of the structure of an antibody; monoclonal means "single type". Therefore, these are tumor cells that all produce the same antibody structure, which indicates they are all derived from a single tumor cell that originally made this antibody structure.
Bevacizumab - it's a monoclonal antibody used in combination with chemotherapy in the treatment of colorectal and lung cancers. And since it's a monoclonal antibody it's very, expensive. To give you an idea it costs roughly $435 per stone of weight (i.e 12 stone person costs $5240) per fortnight (that's about $136,000 a year for a 12 stone person.)
BT-061 is a therapeutic monoclonal antibody that selectively activates regulatory T cells. BT-061 is currently clinically developed by Biotest AG (Germany) for the treatment of autoimmune diseases like Rheumatoid Arthritis and Chronic Plaque Psoriasis. First signs of efficacy with BT-061 and a good tolerability in these indications have been published on scientific congresses (EULAR 2010, Rome; ACR 2010, Atlant).