Mechanism of Enzyme action property of enzyme as catalyst?

Answer 1

The enzyme action can be understand by different theories as: 1 Fischer's lock and key mechanism: This model was proposed by Emil Fischer in 1898. It is also called the tamplate model. According to this model the union of the substrate and the enzyme takes place at the active site more of less in a manner in which a key fits in a lock and results in formation of an enzyme substrate complex. And as the two molecules are involved this hypthesis is also known as the concept of intermolecular fit The ES complex is highly unstabe and almost immideately this complex decompose to produce the end product of the reaction and regenerate the free enzyme. The ES complex results in the release of energy. 2 Koshland's Induced fit model: This model was proposed by Koshland in 1958. He demonstrated that the enzyme molecule does not retain its original shape and structure. But the contact of the substrate induces some configuration or geometrical changes in the active site of the enzyme molecule. Consequnetly the enzyme molecule is made fit completely the configuration of active center of the substrate. At the same time other amino acid residue may become buried in the interior of the molecule. PROPERTIES OF ENZYMES: Enzymes are the protenious catalyst that increase the velocity of biochemical reactions and are not consumed during the reactions they catalysed. They like other catalyst work in specific temprature and pH range and also fit with only specific substrate with their active site. They can trigger the velocity of reaction by 103 to 108 times then uncatalysed reaction. They are some time asssociated with co factors like metals which help them in initiating the reaction.