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The driving distance between Chicago, IL and St. Louis, MO is approximately 300 miles. The driving time would be approximately 5 hours 15 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)

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Q: Miles drive from Chicago to Missouri?
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It is 410.9 Miles and about a 6 and a half hour drive


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According to Mapquest.com it takes 4 hours and 48 minutes to drive the 297 miles from Chicago Illinois to St. Louis Missouri


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