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Why polyclonal antibody tend to have cross-reaction compare to monoclonal antibody?
Polyclonal antibody recognizes several epitopes on the target protein while monoclonal antibody recognizes only single epitope, hence monoclonal antibodies are more specific than polyclonal antibodies. However, sometimes MAbs are not able to precipitate the antigen because the epitope might need to be exposed on the surface of the antigen to be recognized by the antibody. Since some of the epitope might be hidden and it's a single epitope that is recognized by the monoclonal antibody, the propability of the antibody to reconize the epitope is lower compared with the polyclonal antibody that recognizes several epitopes on the target protein this is the reason for the tendency of polyclonal antibodies to have cross-reaction as compared to MAbs. by Victor S Gruezo Jr
Why polyclonal antibody solution is able to precipitate its antigen protein whereas monlclonal antibody solution has hard time to do so?
Polyclonal antibody recognizes several epitopes on the target protein while monoclonal antibody recognizes only single epitope. Sometimes, monoclonal antibodies are not able to precipitate the antigen because the epitope might need to be exposed on the surface of the antigen to be recognized by the antibody. Since the epitope might be hidden and it's a single epitope that is recognized by the monoclonal antibody, the propability of the antibody to reconize the epitope is lower compared with the polyclonal antibody that recognizes several epitopes on the target protein.
Construction and fermentation of Antibody drug?
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope. Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see "Nomenclature of monoclonal antibodies"), and many immunotherapy specialists use the word mab anacronymically.
What are the determinants of investment?
1. Revenue: Economic Growth and Business Cycle 2. Cost: Interest rates and Taxes 3. Expectation: Stable economic and political condition of any country.
How many feet are in several miles?
Several is not a specific amount. It is more than two, but not many and so it does not have a specific value. So there is no specific answer to your question.
What do you learn in university mathematics course?
Math of course! OK, seriously, there are several topics which you learn; what topics you take, and to what level you learn math, depends a lot on the career you choose, and the specific university. Some typical topics include calculus (differentiation, integration, differential equations, etc.), matrixes and determinants, statistics, probability, and many others.
Who played Cleopatra's son?
There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.
What determine an enzymes activity?
There are several things that determine an enzyme's activity. The main determinants include the structure of the enzyme, temperature, pH and so much more.
Use specific in a sentence?
I can give you several sentences.Give me a specific example of that word.I am looking for one specific animal in that herd.This is a specific case.
Is there a monument in Honolulu Hawaii?
There are several. You need to be more specific.
Who is in the US army?
There are SEVERAL Generals. Did you have a specific one in mind?
What did Augustine do?
There are several saints named Augustine. Please be specific.
