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the mayflower set sail September 6, 1620
first off all the Mayflower did not set sale it set SAIL
April 5,1621
1620
On 16 September 1620.
April
The Mayflower set sail September 1620.
3.63
It was 16th of september, 1620
Southampton, England
Southampton
After several mishaps and one return to England due to a leaking sister ship (the Speedwell) the Pilgrims boarded the Mayflower to sail to the New World in on September 6, 1620. They arrived at their destination on November 9, 1620. An excellent web resource for the Mayflower and its famous passengers can be found at: http://www.mayflowerhistory.com/