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Some examples of protective coatings for pharmaceuticals are "sustained release" coatings, which delay dissolution of the drug unit or retard release through restricted diffusion, and "enteric" coatings, which provide protection against the acidic condition of the stomach but dissolve quickly in the more pH neutral environment in the intestine. By manipulating the dissolution pH, some amount of regionally selective drug targeting can be achieved (e.g. early release in the duodenum, intermediate release in the jejunum, later release in the ileum, or even the cecum or post-cecum region (colon region). By manipulating the dissolution rate, some control over the rate of drug accumulation in the body can be achieved, in some cases leading to a prolonged interval of pharmaceutical efficacy for drugs with short half-life in the body.
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