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  1. Take I-64 EAST to I-57 SOUTH.
  2. Continue on I-57 SOUTH to I-24 EAST to Nashville at EXIT 44.
  3. Take I-24 EAST through Illinois and Kentucky and through Nashville to I-75 SOUTH to ATLANTA at EXIT 185A in Chattanooga.
  4. Take I-75 SOUTH through Tennessee and Georgia to I-275 SOUTH to TAMPA and ST. PETERSBURG at EXIT 274. On this stretch, bypass Atlanta, Georgia by taking I-285 WEST BYPASS (EXIT 259 off I-75 and then EXIT 58 off I-285 to get back onto I-75 SOUTH) and bypass Macon, Georgia by taking I-475 SOUTH (EXIT 177 off I-75).
  5. Take I-275 SOUTH to the Tampa Bay Area.
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Q: Shortest driving route St. Louis to Tampa Bay?
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