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These are straight from the CDC. Persons receiving prolonged therapy with corticosteroids and other immunosuppressive agents may be at risk for reactivation of TB, but the exact risk is unknown (1). Because prednisone (or its equivalent) given >15 mg/d for 2--4 wk suppresses tuberculin reactivity (55,56), and because lower doses or those given intermittently are not associated with TB, this dose is likely the lower limit that could predispose persons to develop TB (57). Reactivation of TB is more likely to occur in persons receiving higher doses of corticosteroids for prolonged periods of time, especially in populations at high risk for TB, but specific thresholds of dose and duration that could increase the risk for TB are unknown For persons who are at highest risk for developing TB disease if they become infected with M. tuberculosis, a cut-off level of >5 mm is recommended. Persons who are immunosuppressed because of disease (e.g., HIV infection) or drugs (e.g., systemic corticosteroids) have a high likelihood of developing TB disease if they are infected with M. tuberculosis. Previous BCG vaccination. Intracutaneous inoculation with BCG is currently used in many parts of the world as a vaccine against tuberculosis. Tuberculin reactivity caused by BCG vaccination generally wanes with the passage of time but can be boosted by the tuberculin skin test. Periodic skin testing may prolong reactivity to tuberculin in vaccinated persons (74). No reliable method has been developed to distinguish tuberculin reactions caused by vaccination with BCG from those caused by natural mycobacterial infections, although reactions of >20 mm of induration are not likely caused by BCG (75). HIV infection and anergy testing. HIV-infected persons may have a compromised ability to react to tuberculin skin tests because of cutaneous anergy associated with progressive HIV immunosuppression (76). However, the usefulness of anergy testing in selecting tuberculin-negative, HIV-infected persons who might benefit from treatment of LTBI has not been demonstrated (77). Who Can Receive a TST?Most persons can receive a TST. TST is contraindicated only for persons who have had a severe reaction (e.g., necrosis, blistering, anaphylactic shock, or ulcerations) to a previous TST. It is not contraindicated for any other persons, including infants, children, pregnant women, persons who are HIV-infected, or persons who have been vaccinated with BCG

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Q: Should employee health conduct a PPD skin test on an immunocompromised healthcare worker?
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