Blood and urine test
Amyloid proteins are manufactured by malfunctioning bone marrow. Amyloidosis, which occurs when accumulated amyloid deposits impair normal body function, can cause organ failure or death.
If no shock is indicated by the AED, check for signs of life. Continue CPR if no signs of life are present.
AmyloidosisIn medicine, amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues. A protein is described as being amyloid if, due to an alteration in its secondary structure, it takes on a particular aggregated insoluble form similar to the beta-pleated sheet. Symptoms vary widely depending upon the site of amyloid deposition. Amyloidosis may be inherited or acquired.(Extracted from Wikipedia.)
An amyloid is a waxy compound of protein and polysaccharides which is found deposited in tissues in amyloidosis.
There are several proteins that are associated with detrimental effects in the body. Some examples include amyloid beta, tau protein, prions, and misfolded proteins involved in neurodegenerative diseases like Alzheimer's and Parkinson's. These proteins can disrupt normal cellular function and lead to diseases and disorders.
== == Amyloid beta (AB) protein is produced from the cleavage of amyloid precursor protein (APP: a transmembrane protein) by beta secretase and gamma secretase. The build up of this intact AB protein leads to formation of amyloid plaques. Tau is a group of microtubule associated proteins which contributes to the assembly and stabilization of microtubules in axons. However, hyperphosphorylation of tau leads to tau aggregation and formation of neurofibrillary tangles (NFT). Intracellular NFT and extracellular amyloid plaques are two pathological hallmarks of Alzheimer's disease.
Cerebral amyloid angiopathy (CAA) is also known as congophilic angiopathy or cerebrovascular amyloidosis.
Acidic Congo red stain is a synthetic dye that is based on the structure of azo compounds, which contain an azo group (-N=N-). It is an anionic dye, meaning it carries a negative charge, and is used primarily in histology to detect amyloid deposits in tissues, as it binds to the β-pleated sheet structure characteristic of amyloid proteins. Upon binding, Congo red exhibits a characteristic red color, and under polarized light, it displays a green birefringence, which is indicative of amyloid presence.
A disorder marked by deposition of amyloid in the body. a rare disease which causes the build-up of amyloid, a protein, & starch, it can get in tissues and organs.
laboured or no signs of breathing/Choking.
If no shock indicated, check for signs of life; and if none continue CPR until the AED analysis's again.
Vital signs are always indicated. In every patient, trauma or medical, stable or unstable. Always, ALWAYS, check vitals.