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== == Amyloid beta (AB) protein is produced from the cleavage of amyloid precursor protein (APP: a transmembrane protein) by beta secretase and gamma secretase. The build up of this intact AB protein leads to formation of amyloid plaques. Tau is a group of microtubule associated proteins which contributes to the assembly and stabilization of microtubules in axons. However, hyperphosphorylation of tau leads to tau aggregation and formation of neurofibrillary tangles (NFT). Intracellular NFT and extracellular amyloid plaques are two pathological hallmarks of Alzheimer's disease.
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What is the difference between a normal tertiary structure of a prion and an infected prion structure?
In normal prions, the protein folds into a predominantly alpha-helical structure. However, in infected prions, the protein misfolds into a beta-sheet-rich conformation, leading to aggregation and formation of amyloid plaques. This misfolding is responsible for the infectious nature of prions.
What is the difference between a beta plus particle and a beta minus particle?
The difference between a beta plus and beta minus particle is the electrical charge. The charges are equal, but opposite. The beta minus particle is an electron with a negative charge, while the beta plus particle is an anti-electron or positron with a positive charge.
Does prions cause Alzheimers?
No, prions do not cause Alzheimer's disease. Alzheimer's is characterized by the accumulation of beta-amyloid plaques and tau protein tangles in the brain, while prion diseases, such as Creutzfeldt-Jakob disease, are caused by misfolded prion proteins that lead to brain damage and cell death through a different mechanism.
What level of molecular organization is a beta-folded sheet?
A beta-folded sheet is a secondary structure of a protein, which is the next level of molecular organization above the primary structure. It is formed by hydrogen bonding between adjacent segments of a polypeptide chain, creating a flat and elongated sheet-like structure.
What is the difference between alpha carotene and beta carotene?
Alpha carotene and beta carotene are both forms of carotenoids, which are plant pigments converted into vitamin A in the body. The main difference is in their molecular structure, with alpha carotene having one more double bond than beta carotene. Both are powerful antioxidants, but research suggests that beta carotene may be more potent and have higher levels in certain foods like carrots and sweet potatoes.
Why does tau overexpression and deposits of amyloid beta protein inside and between neurons cause the neurons to die?
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What is the difference between a normal tertiary structure of a prion and an infected prion structure?
In normal prions, the protein folds into a predominantly alpha-helical structure. However, in infected prions, the protein misfolds into a beta-sheet-rich conformation, leading to aggregation and formation of amyloid plaques. This misfolding is responsible for the infectious nature of prions.
Does estrogen decrease production of beta-amyloid?
Yes, estrogen has been shown to influence the production of beta-amyloid, a protein associated with Alzheimer's disease. Research suggests that estrogen may help reduce the production and accumulation of beta-amyloid in the brain, potentially providing a protective effect against neurodegeneration. However, the exact mechanisms and implications of estrogen's role in this process are still being studied, and findings can vary based on factors like age and hormonal status.
What is protein type AAA?
AmyloidosisIn medicine, amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues. A protein is described as being amyloid if, due to an alteration in its secondary structure, it takes on a particular aggregated insoluble form similar to the beta-pleated sheet. Symptoms vary widely depending upon the site of amyloid deposition. Amyloidosis may be inherited or acquired.(Extracted from Wikipedia.)
What causes the hereditary form of CAA?
In hereditary CAA, genetic defects, typically on chromosome 21, allow accumulation of amyloid, a protein made up of units called beta-pleated sheet fibrils. The fibrils tend to clump together, so that the amyloid cannot be dissolved.
What does amyloid substances resemble?
Amyloid substances resemble fibrous protein aggregates that have an abnormal structure, often forming insoluble plaques. They typically have a beta-sheet configuration and can appear as elongated fibrils under an electron microscope. In tissues, they can create a waxy, translucent appearance and are commonly associated with various diseases, such as Alzheimer's and amyloidosis.
Where does solanezumab derive from?
Solanezumab is a monoclonal antibody that was developed by Eli Lilly and Company. It specifically targets amyloid-beta peptides, which are associated with the formation of amyloid plaques in the brains of Alzheimer's disease patients. The antibody was designed to bind to soluble forms of amyloid-beta, aiming to modify the disease's progression. Its development was part of ongoing research into potential therapies for Alzheimer's.
Alzheimer's disease is most closely linked to the loss of neurons that produce?
its a chemical inbalance that doesnt let oxygen flow right to the areas that it needs to pretty much in elderly people this happends alot the lost memory, they sometimes dont remember names but they could at times recognize voices i work in a nursing home n i see alot of this situations they could remember one day the next u dont even exist i just hope that god helps the same way i help them
Difference between beta and standard deviation?
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What is plaque on the brain?
Do you mean brain plaque? Amyloid plaques in the brain generally are found in people who suffer from Alzheimer's disease. According to RxList.com, these plaques are bunches of beta amyloid protein and small fragments of neurons. The plaques float in the tissue that surrounds and lies between nerve cells. As yet, scientists are not clear about whether these plaques are side effects of Alzheimer's or may be harmful themselves. Brain Plague is a science fiction book.
Is beta galactosidase a protein?
Yes, beta galactosidase is a protein.
What is the difference between Gamma and Beta burns?
"beta burns" are shallow surface burns
