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Some people eith a deficit of IgA exhibit recurrent paranasal sinus and respiratory tract infections Explain these symptoms?
Wiki User
∙ 14y ago
Immunoglobulin A (IgA) is an antibody playing a critical role in mucosal immunity. More IgA is produced in mucosal linings than all other types of antibody combined. In its secretory form, it is the main immunoglobulin found in mucous secretions, including tears, saliva, colostrum, intestinal juice, vaginal fluid and secretions from the prostate and respiratory epithelium. Because it is resistant to degradation by enzymes, secretory IgA can survive in harsh environments such as the digestive and respiratory tracts, to provide protection against microbes that multiply in body secretions.
Because the respiratory tract and sinus cavities are mucosal entities, the infections manifest here.
Wiki User
∙ 14y ago
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