There are many structure activity relationship studies of Aspirin. Some of them are one to things, while others have found a great deal of knowledge.
Quantitative structure-activity relationship (QSAR)(sometimes QSPR: quantitative structure-property relationship)QSAR is the process by which chemical structure is quantitatively correlated with a well defined process, such as biological activity or chemical reactivity.For example, biological activity can be expressed quantitatively as in the concentration of a substance required to give a certain biological response. Additionally, when physicochemical properties or structures are expressed by numbers, one can form a mathematical relationship, or quantitative structure-activity relationship, between the two. The mathematical expression can then be used to predict the biological response of other chemical structures.http://en.wikipedia.org/wiki/Quantitative_structure-activity_relationship
Yvonne Connolly Martin has written: 'Quantitative drug design' -- subject(s): Biopharmaceutics, Theoretical Models, Drugs, Drug Design, QSAR (Biochemistry), Design, Structure-activity relationships, Quantitative Structure-Activity Relationship 'Quantitative drug design' -- subject(s): Drugs, Structure-activity relationships, Biopharmaceutics, Theoretical Models, Drug Design, QSAR (Biochemistry), Design, Quantitative Structure-Activity Relationship, Mathematical models
QSP stands for Quantitative Structure-Activity Relationship. It is a computational method used in drug discovery to predict the biological activity of chemical compounds based on their structure and physicochemical properties.
Benzene has a stable structure. Aspirin has an carboxylic group with delocalized electrons. So aspirin is more reactive than benzene.
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More correctly it is called antiplatelet aggregation drugs (also called antithrombotic drugs) that include aspirin, clopidogrel, abciximab (monoclonal antibodies) and GPII/ IIIA receptors antagonists etc. Each drug has its own way and mechanism of action. It depends upon chemical structure of drug and site of action. Aspirin blocks aggregation by inhibiting cycloxygenase that produce thromboxane A2 that causes platelet aggregation. Clopidogrel acts as antagonist to P2Y2 receptors present on platelets required for their aggregation. You can check for further details. Umar Mujahid Pharm.D u.mujahid@yahoo.com
The relationship between physical activity and cardiovascular activity is that physical activity changes body organs, which results in improved cardiovascular fitness. hope this helps :)
Of course not! There is no relationship between the two chemical compounds.
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Guo-Qiang Lin has written: 'Chiral drugs' -- subject(s): Pharmaceutical Preparations, Methods, Structure-Activity Relationship, Drug development, Chiral drugs, Drug Discovery, Chemistry, Structure-activity relationships (Biochemistry) 'Principles and applications of asymmetric synthesis' -- subject(s): Asymmetric synthesis
Siyu Liu has written: 'Antithrombotic/antiplatelet properties and mechanism of action of tetramethylpyrazine, including structure-activity relationship studies' -- subject(s): Pyridazines
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