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The first mesaage that Muhammad received was that allahtold him that you are my prophet and you will spread Islam
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Imam Ali S.A. was cousin of prophet and prophet selected him as spiritual brother.Answer IIQuestion is historically wrong ,so is above given answer ( With due apology to respected contributor ) As H . Ali RA was not uncle of Prophet Muhammad, But H. Hamza RA was uncle of prophet Muhammad who was also Rizzae brother of prophet Muhammad pbuh .
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Prophet Muhammad (peace upon him) started preaching in Makkah (Mecca) in year 610 AD (year of Quran start of revelation by God).
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It was written once. He memorized every word as it was given to him. The last part... was given to him on his deathbed.
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Prophet Muhammed (PBUH) is the most famous prophet because he was the last and Allah's favorite prophet. He was given the Quran which is now are official holy book and he was a good kind man.