By car: take I-15 South. It is about 330 miles and takes about five and a half hours.
The flight from Airport to airport takes a little more than one hour and a one way ticket can cost $170.
The driving distance between Las Vegas, NV and San Diego, CA is approximately 325 miles. The driving time would be approximately 5 hours 15 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)
about 5 hours
331 miles
The driving distance between San Diego and Las Vegas is 332 miles.
San Diego, California
Las Vegas is farther west
375
The highway
Las Vegas and San diego
5 - 6 hours
327 miles
The fastest way to get from San Francisco to Las Vegas is by using I-5 in California. You can then travel on I-15 N from there to reach Las Vegas, NV.
5 hours